Photogallery, the "indicator" protein fibers of dementia

AFM images of proteins that combine into strips several hundred nanometers long on red blood cells with Alzheimer's disease

Correlation between the age of patients and the memory and cognitive abilities of people affected by Alzheimer's disease
Correlation between the age of patients and the memory and cognitive abilities of people affected by Alzheimer's disease

A team made up of scientists from the Swiss Federal Laboratories for Materials Science and Technology and Cantonal Hospital of St. Gallen is developing one special blood test, which will allow a reliable diagnosis of the onset of Alzheimer's disease thanks to the use of Atomic Force Microscopy.
The body Peter Nirmalraj wanted to understand the mechanisms that preside over the molecular pathogenesis of senile dementia to allow for new approaches in diagnosis and therapy, deciphering the exact role of the Beta-Amyloid Peptides and Tau protein associated with neurodegenerative diseases, mainly determining the variable form and their amount.
The researcher therefore decided to work on technologies that allow blood observations su nanoscale, without however destroying the structure and morphology of the protein.
In case of finding an effective and almost painless blood test, patients with suspected Alzheimer's disease would be spared the unpleasant lumbar puncture for the withdrawal of cerebrospinal fluid, which is necessary today in order to be able to diagnose the disease reliably.
For research, the team looked into blood samples di 50 patients need 16 healthy subjects using the AFM technology, through an analysis of the surface of approx 1.000 red blood cells for each person without knowing anything about theirs health state.
The researchers were able to determine a pattern that matches the stage of the patients' disease: those affected by the Alzheimer's disease they had large quantities of protein fibers composed of Beta-Amyloid Peptides e Tau protein.
these protides they were able to combine into long fibers diverse hundreds of nanometers. in healthy individuals or with incipient brain disorders, however, the scientist from St. Gallen only counted few protein accumulations of this type.

In Switzerland, the signs of Alzheimer's detected in the blood
Video, the new blood tests to "find out" Alzheimer's

3D image of red blood cells viewed with the Atomic Force Microscope
3D image of red blood cells viewed with the Atomic Force Microscope